| 发明名称 |
Preparation of 4-Amino-2,4-Dioxobutanoic Acid |
| 摘要 |
A process for synthesizing 4-amino-2,4-dioxobutanoic acid involves reacting diethyl oxalate with an alkoxide in ethanol to form a reaction mixture, and afterward adding ethyl cyanoacetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl 2-cyano-3-hydroxy-butenedioate, and then isolating the diethyl 2-cyano-3-hydroxy-butenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with an aqueous hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoic acid. |
| 申请公布号 |
US2015065750(A1) |
申请公布日期 |
2015.03.05 |
| 申请号 |
US201414486423 |
申请日期 |
2014.09.15 |
| 申请人 |
Los Alamos National Security, LLC ;New Mexico Highlands University |
发明人 |
Unkefer Pat J.;Martinez Rodolfo A.;Glass David R. |
| 分类号 |
C07C231/06;C07C253/30 |
主分类号 |
C07C231/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for synthesizing 4-amino-2,4-dioxobutanoic acid, comprising:
reacting diethyl oxalate with an alkoxide in an alcoholic solvent form a reaction mixture, and afterward adding ethyl cyanoacetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl 2-cyano-3 -hydroxy-butenedioate, isolating said first reaction product of diethyl 2-cyano-3-hydroxy-butenedioate, reacting said first reaction product of diethyl 2-cyano-3-hydroxy-butenedioate with aqueous hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoic acid. |
| 地址 |
Los Alamos NM US |
