发明名称 |
METHOD AND COMPOSITION FOR ENHANCING THE DELIVERY OF ANTI-PLATELET DRUGS FOR THE TREATMENT OF ACUTE STROKE |
摘要 |
The invention provides a method for enhancing the delivery of an anti-platelet drug for the treatment of acute stroke, comprising delivering a composition comprising an anti-platelet drug and a vehicle that can reduce the binding rate of plasma proteins, so that the anti-platelet drug can achieve the effect of treating acute stroke at a low dose. By use of the neuro-protective efficacy of anti-platelet drug, the invention allows the drug to release slowly to the site of treatment by combining anti-platelet drugs with a vehicle that can reduce the binding rate of plasma proteins to effectively reduce the dose of the anti-platelet drug and consequently reduce the side effects such as hypotension caused by, administration of a high dose of the anti-platelet drugs. The invention also provides a pharmaceutical composition for enhancing treatment of acute stroke and a method for treating acute stroke using the pharmaceutical composition of the invention. |
申请公布号 |
US2015064238(A1) |
申请公布日期 |
2015.03.05 |
申请号 |
US201414444259 |
申请日期 |
2014.07.28 |
申请人 |
Lin Jen Cheng |
发明人 |
Lin Jen Cheng;Lin Chun-Chieh;Lee Hsu-Tung;Fan Yu-Ming;Tsai Jui-Chi |
分类号 |
A61K47/34;A61K45/06;A61K31/519 |
主分类号 |
A61K47/34 |
代理机构 |
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代理人 |
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主权项 |
1. A method for enhancing the delivery of an anti-platelet drug for the treatment of acute stroke, comprising delivering a composition comprising
(a) an anti-platelet drug; and (b) a vehicle or chemical modification thereof that can reduce the binding rate of plasma proteins, so that the anti-platelet drug can achieve the effect of treating acute stroke at a low dose, wherein the effective amount of the anti-platelet drug is about 30 to 100 mg, and the anti-platelet drug is a phosphodiesterase inhibitor. |
地址 |
Keelung City TW |