Quantified differentiation and identification of changes in tissue by enhancing differences in blood flow and metabolic activity

摘要

The invention provides a novel quantitative method for differentiating and identification of changes in tissue by enhancing differences in blood flow prior to administering a radiopharmaceutical, which differentially accumulates in tissue based upon differences in blood flow and metabolic activity. In one embodiment the enhancing agent is 0.852 mg per kilogram body weight dipyridamole and the radiopharmaceutical is Technetium-99m hexakis 2-methoxyisobutylisonitrile (sestamibi) and the tissue differentiation is calcification, normal, inflammatory, precancerous and cancerous breast tissue. The present invention allows differentiation between regions of calcification, nonliving or metabolically inactive tissue, normal tissue, pre-cancerous and cancerous tissue. The present invention allows for quantification of changes in tissue to determine the effect of treatment upon tissue.

主权项

1. A method for quantifying, differentiating and identifying differences in tissue based upon differences in metabolic activity and blood flow, which when sufficiently enhanced physiologically and/or pharmacologically can differentially enhance blood flow in regions of inflammation, precancerous and cancerous tissue, allowing for tissue differentiation, identification and quantification:
a. The quantifying of isotope emission from tissue following this enhancement in blood flow to tissues of different metabolic activity and blood flow; b. The quantification being performed by any detector of isotope emissions, including but not limited to planar detection, single photon emission computed tomography (SPECT) detectors, positron emission tomography (PET) detectors, semiconductor detectors, Geiger counters and/or other suitable devices; c. From any organ system to make a diagnostic and/or treatment decision; d. Both on an initial evaluation and subsequent evaluations; e. Including the monitoring of treatment effectives.