发明名称 |
PRODUCTS AND METHODS FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS |
摘要 |
The present invention relates to RNA-based methods for inhibiting the expression of the superoxide dismutase 1 (SOD-1) gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding RNAs that knock down the expression of SOD-1. The methods have application in the treatment of amyotrophic lateral sclerosis. |
申请公布号 |
CA2922500(A1) |
申请公布日期 |
2015.03.05 |
申请号 |
CA20142922500 |
申请日期 |
2014.08.26 |
申请人 |
RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL;LUDWIG INSTITUTE FOR CANCER RESEARCH, LTD |
发明人 |
KASPAR, BRIAN K.;FOUST, KEVIN;CLEVELAND, DON W. |
分类号 |
C12N15/86;A61P25/28;C12N9/02;C12N15/113 |
主分类号 |
C12N15/86 |
代理机构 |
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代理人 |
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地址 |
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