摘要 |
<p>#CMT# #/CMT# Implant comprises a coating containing a functionalized Arg-Gly-Asp peptide chosen from Arg-Gly-Asp-P1 (I) and Arg-Gly-As-P2 (II). #CMT# : #/CMT# Implant comprises a coating containing a functionalized Arg-Gly-Asp peptide chosen from Arg-Gly-Asp-P1 of formula (I) and Arg-Gly-Asp-P2 of formula (II). Q,T,U,V : O or NH; A : O or (CH 21 - 3; X : CH 2, O, N or S; Y' : CH 2,O,N or S; Z,M : O or S; n,r : 1-6; m : 2-8; p : group chosen from alkylene, (CH 2) 1 - 6, or aromatic or aliphatic N and O-cycloalkyl (all optionally substituted);and R : polymeric group chosen from chitosan and polylysine (poly-D-lysine or poly-L-lysine). (i) When A is O, X is CH 2; and (ii) Where O is not 0equal to T and U is not equal to V. An independent claim is included for method for manufacturing the implant, which involves forming covering layer, base layer and active ingredient-setting free layer, where the covering layer comprises Arg-Gly-Asp peptide and its precursor of formula (III). #CMT#[Image]#/CMT# #CMT#[Image]#/CMT# #CMT#[Image]#/CMT# #CMT#USE : #/CMT# The implant chosen from stent, sensor or electrode is useful for delivering active ingredient chosen from paclitaxel, sirolimus and/or rapamycin, preferably sirolimus (claimed). #CMT#BIOTECHNOLOGY : #/CMT# Preferred Implant: The functionalised RGD peptide is incorporated into covering layer. The coating comprises a base layer which comprises an active ingredient-setting free layer. The implant is a stent, sensor or electrode. The stent comprises a resorbable or permanent polymeric material. #CMT#EXAMPLE : #/CMT# No suitable example given.</p> |