发明名称 |
COMBINATION OF CD37 ANTIBODIES WITH BENDAMUSTINE |
摘要 |
<p>The present invention relates to immunotherapies that are based on depletion of CD37-positive cells such as B-cells. The present invention provides methods for reduction of CD37-positive cells such as B-cells in an individual/patient using a combination of CD37 antibody/antibodies and bendamustine. The combination of CD37 antibodies and bendamustine is shown to have a synergistic effect. The application further provides materials and methods for treatment of diseases involving aberrant B-cell activity.</p> |
申请公布号 |
EP2841099(A1) |
申请公布日期 |
2015.03.04 |
申请号 |
EP20130719507 |
申请日期 |
2013.04.25 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
HEIDER, KARL-HEINZ;BLUM, PETRA |
分类号 |
A61K39/395;A61K31/4184;A61P35/02;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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