发明名称 |
PROCESS FOR EX VIVO EXPANSION OF STEM CELLS IN A BIOREACTOR |
摘要 |
The present invention refers to a process of ex vivo expansion of stem cells, in a bioreactor, in particular hematopoietic stem/progenitor cells co-cultured with mesenchymal stem cells immobilized on microcarriers, for transplantation. The process comprises the steps of: a) forming a suspension of mesenchymal stem cells immobilized on microcarriers, b) inoculating in a bioreactor containing an expansion medium, hematopoietic cells co-cultured with mesenchymal stem cells immobilized on microcarriers c) expansion of hematopoietic cells. The process of the invention is capable of being implemented in a Kit. |
申请公布号 |
EP2841560(A2) |
申请公布日期 |
2015.03.04 |
申请号 |
EP20130713584 |
申请日期 |
2013.03.19 |
申请人 |
INSTITUTO SUPERIOR TÉCNICO |
发明人 |
CABRAL, JOAQUIM MANUEL SAMPAIO;SILVA, CLÁUDIA ALEXANDRA MARTINS LOBATO DA;ANDRADE, PEDRO MIGUEL ZACARIAS;SANTOS, FRANCISCO FERREIRA DOS;ALMEIDA-PORADA, MARIA DA GRAÇA NORTADAS DUARTE DE |
分类号 |
C12N5/00;C12N5/0789 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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地址 |
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