发明名称 |
Flavonoid compounds and process for preparation thereof |
摘要 |
The present invention relates to flavanoid compounds of general formula (X1) wherein: R1 is selected from a group consisting of morpholinyl, N-methyl piperizinyl, piperidinyl and N,N′-dimethylamino groups, and n ranges from 3 to 6, and process for preparation thereof. The present invention relates to the demonstration of anti Helicobacter pylori activity and gastric antisecretory activity of semisynthetically designed flavonoid compounds, to be used for the prevention and treatment of gastroduodenal disorders in general and peptic ulcer diseases in particular. The present invention also relates to a hetero-dimeric bi-functional molecule that can be used as monotherapy substituting/replacing/overcoming currently used triple/quadruple therapy, thereby implicating/anticipating/envisaging its commercial applicability.; |
申请公布号 |
US8969384(B2) |
申请公布日期 |
2015.03.03 |
申请号 |
US201013203702 |
申请日期 |
2010.02.26 |
申请人 |
Council of Scientific & Industrial Research |
发明人 |
Das Pratap Kumar;Goswami Suchandra;Chinniah Annalakshmi;Rao Janaswamy Madhusudana;Katragadda Suresh Babu |
分类号 |
A61K31/453;C07D311/30 |
主分类号 |
A61K31/453 |
代理机构 |
DLA Piper LLP (US) |
代理人 |
DLA Piper LLP (US) |
主权项 |
1. A method for inhibiting the growth of Helicobacter pylori in a subject, comprising administering to the subject a therapeutically effective amount of a compound, wherein the compound is 5-hydroxy-2-phenyl-7-(6-piperidin-1-yl-hexyloxy)-chromen-4-one (CPP-1), or a pharmaceutically acceptable salt thereof. |
地址 |
New Delhi IN |