Treatment of skin and mucosal superficial wounds using adrenergic receptor agonists

摘要

The invention generally relates to the compositions and methods related to the use of adrenergic receptor agonists solutions for the treatment of skin and mucosal superficial wounds. Some of the preferred adrenergic receptor agonists include epinephrine, phenylephrine, norepinephrine, methoxamine, and mixtures thereof. The invention also relates to devices suitable for applying these solutions to the skin or the mucosal area. Methods according to the invention are especially effective to control superficial skin and mucosal bleeding and accelerate healing time.

主权项

1. A disposable dispenser comprising a cap cover, a sponge cap, a hollow shaft with a perforator, and a dispensing part comprising a sterile solution suitable for a topical application to a superficial skin or mucosal wound consisting essentially of: a) an adrenergic receptor agonist, wherein said adrenergic receptor agonist is selected from the group consisting of epinephrine hydrochloride, phenylephrine hydrochloride, norepinephrine hydrochloride, methoxamine hydrochloride, and mixtures thereof, at a concentration of about 0.1 mg/ml to about 2.5 mg/ml, b) an acidifying agent, wherein said acidifying agent is selected from the group consisting of sodium citrate, potassium citrate, sodium lactate, and mixtures thereof and c) one local anesthetic agent, wherein said anesthetic agent is selected from the group consisting of bupivacaine, lidocaine, chloroprocaine, dibucaine, etidocaine, tetracaine, and procaine.