| 发明名称 | Serum albumin binding molecules | ||
| 摘要 | The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications. | ||
| 申请公布号 | US8969289(B2) | 申请公布日期 | 2015.03.03 |
| 申请号 | US201113098851 | 申请日期 | 2011.05.02 |
| 申请人 | Bristol-Myers Squibb Company | 发明人 | Gosselin Michael L.;Fabrizio David;Swain Joanna F.;Mitchell Tracy;Camphausen Ray;Cload Sharon T.;Furfine Eric;Morin Paul E.;Mukherjee Ranjan;Taylor Simeon I. |
| 分类号 | C07K14/00;A61K47/48;C12N15/62;C07K14/78;A61K38/00 | 主分类号 | C07K14/00 |
| 代理机构 | Nelson Mullins Riley & Scarborough LLP | 代理人 | Nelson Mullins Riley & Scarborough LLP ;Remillard, Esq. Jane E.;Kanik Cynthia L. |
| 主权项 | 1. A polypeptide comprising a fibronectin type III tenth (10Fn3) domain, wherein the 10Fn3 domain binds to human serum albumin with a KD of 1 μM or less, wherein the 10Fn3 domain comprises a modified amino acid sequence in one or more of the BC, DE and FG loops relative to the wild-type human 10Fn3 domain (SEQ ID NO: 1), and wherein the polypeptide comprises an amino acid sequence at least 75% identical to an amino acid sequence selected from SEQ ID NOs: 4, 8, 12, 16, 20, and 24-44. | ||
| 地址 | Princeton NJ US | ||