Methods for diagnosing and treating loss or distortion of taste

摘要

The invention is directed to a method of detecting a biological substance in the nasal secretion and diagnosing a disease following the detection of the biological substance wherein the biological substance is not related to a respiratory disease. The invention also provides treatment of the diseases following the detection of the biological substance and/or diagnosis of the disease. In some embodiments, the diseases are cancer, hepatitis, smell loss, taste loss, diabetes, and leprosy. The invention also provides a kit for diagnosing a disease.;The present invention includes methods of analyzing samples from the nose for the detection of biological substances. In particular, nasal secretion or nasal mucus is collected and analyzed for biological substances. The results of this analysis are then suitable for use in diagnosis, prognosis, and determination of suitability of therapeutic interventions.

主权项

1. A method comprising:
(i) detecting a cyclic nucleotide level in a human nasal mucus or human saliva specimen; (ii) comparing the cyclic nucleotide level of the nasal mucus or saliva specimen to a cyclic nucleotide level of a control population; and (iii) diagnosing loss or distortion of taste in the human based on a decreased level of the cyclic nucleotide for the nasal mucus or saliva specimen compared to the cyclic nucleotide level of the control population, wherein the cyclic nucleotide level is detected by an immunoassay; and wherein the method further comprises determining at least one of a detection threshold (DT), a recognition threshold (RT), or a magnitude estimation (ME) for four tastants: sodium chloride (NaCl), sucrose, hydrogen chloride (HCl) and urea.