| 发明名称 | 18β-Glycyrrhetinic acid derivatives and synthetic method thereof | ||
| 摘要 | The present invention provides a chemical compound having the structure being one selected from a group consisting of; wherein R1 is one selected from a group consisting of COOCH3, COOCH2Ph, CONHCH(CH3)2 and CONHC6H5, R2 is one selected from a group consisting of H, CH3 and CH(CH3)2, R3 is one selected from a group consisting of H, CH3, CH(CH3)2 and CH2Ph, and R4 is one of CH(CH3)2 and C6H5. | ||
| 申请公布号 | US8969617(B2) | 申请公布日期 | 2015.03.03 |
| 申请号 | US201213675574 | 申请日期 | 2012.11.13 |
| 申请人 | Kaohsiung Medical University | 发明人 | Lin Chun-Nan;Maitraie Dravidum;Wang Jih-Pyang;Hung Chi-Feng;Tu Huang-Yao;Liou Ya-Ting;Wei Bai-Luh;Yang Shyh-Chyun |
| 分类号 | C07C61/12;C07C69/74;C07D313/06;A61K31/19;A61K31/215;A61K31/335;C07D313/08;C07J63/00;C07J73/00;C07C231/02;C07C231/12 | 主分类号 | C07C61/12 |
| 代理机构 | Volpe and Koenig, P.C. | 代理人 | Volpe and Koenig, P.C. |
| 主权项 | 1. A method for synthesizing a chemical compound having a structure ofwherein R1 is one of CONHCH(CH3)2 and CONHC6H5, the method comprising steps of: (a) oxidizing 18β-glycyrrhetinic acid using CrO3 in dimethyl formamide to form a first compound having a structure ofwhere R is H; (b) oxidizing the first compound with m-chloroperbenzoic acid to form a lactone compound having a structure ofand (c) amidating an acid group at C-30 of the lactone compound with an amine to obtain the chemical compound, wherein the amine is an isopropylamine when R1 is CONHCH(CH3)2, and the amine is an aniline when R1 is CONHC6H5. | ||
| 地址 | Kaohsiung TW | ||