Hydrogel implants with varying degrees of crosslinking

摘要

The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

主权项

1. A hydrogel composition comprising:
a first reactive precursor comprising a multi-arm polyether possessing electrophilic groups; a second reactive precursor comprising nucleophilic groups; and at least one initiated precursor selected from the group consisting of phosphorylcholine containing monomers, furanone functional vinyl monomers, N-vinyl pyrrolidone, siloxane functional vinyl compounds, polyethylene glycol-silicone co-monomers having vinyl groups, pyrrole, liquid crystalline vinyl monomers, liquid crystalline vinyl polymers, and combinations thereof, wherein the first reactive precursor is reactive with the second reactive precursor to form a first hydrogel, and the initiated precursor forms a second hydrogel upon exposure with an initiator.