Combination degradable and non-degradable matrices for active agent delivery

摘要

The present invention relates to relates to combination degradable and non-degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.

主权项

1. A method of making an active agent delivery matrix comprising:
mixing a degradable polymer with a first polar solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second non-polar solvent that is immiscible with the first polar solvent to form a non-degradable polymer solution, wherein the non-degradable polymer comprises a first polymer component comprising a polymer selected from poly(alkyl(meth)acrylate), poly(aromatic(meth)acrylate), and combinations thereof and a second polymer component comprising poly(ethylene-co-vinyl acetate); and simultaneously depositing the degradable polymer solution onto a substrate by spraying the degradable polymer solution from a first spray nozzle while simultaneously spraying the non-degradable polymer solution onto the substrate from a second spray nozzle to form an active agent delivery matrix in which the degradable polymer network and the non-degradable polymer network form an interpenetrating matrix, wherein the active agent delivery matrix comprises from 15 wt. % to 50 wt. % degradable polymer and from about 20 wt % to about 60 wt % non-degradable polymer.