| 主权项 |
1. A plurality of implantable drug depots useful for reducing, preventing or treating pain and/or inflammation in a patient in need of such treatment, the plurality of drug depots comprising a first set of one or more drug depots capable of releasing a therapeutically effective bolus dose of an analgesic and/or an anti-inflammatory agent or pharmaceutically acceptable salts thereof at a site beneath the skin and a second set of one or more drug depots capable of releasing a therapeutically effective amount of the analgesic and/or the anti-inflammatory agent or pharmaceutically acceptable salts thereof over a period of at least three days, the first set of one or more drug depots and the second set of one or more drug depots being solid and separate from each other and the second set of one or more drug depots comprises a polymer having an average molecular weight of between about 10,000 to 100,000, wherein the analgesic comprises alfentanil, butorphanol, codeine, fentanyl, hydromorphone, levorphanol, meperidine, morphine, sufentanil, tramadol or a combination thereof, and the anti-inflammatory agent comprises clonidine, fluocinolone, dexamethasone, sulindac, sulfasalazine or a combination thereof, and each depot of the first and second set comprises a pore forming agent, wherein the pore forming agent is polyethylene glycol or N-methyl-2-pyrrolidone, and each depot of the first and second set comprises an inherent viscosity from about 0.10 dL/g and 1.2 dL/g, and each depot of the first and second set comprises an adherent gel, wherein the gel stiffens after delivery to a target site having a pre-dosed modulus of elasticity of about 1×104 to about 3×105 dynes/cm2 and a post-dosed modulus of elasticity of about 1×105 to about 7×105 dynes/cm2. |
