Hydrophilic polymer microparticle, filler for ion exchange liquid chromatography, and method for production of filler for ion exchange liquid chromatography

摘要

The present is a hydrophilic polymer microparticle, which has a DW/DA ratio of 2.0 or less, the DW representing a particle diameter of the hydrophilic polymer microparticle dispersed in water, the DA representing a particle diameter of the hydrophilic polymer microparticle dispersed in acetone, each of the particle diameters measured by a particle size distribution analyzer after the hydrophilic polymer microparticle is dispersed in water or acetone, subjected to irradiation with ultrasonic waves for 15 minutes, and allowed to stand at a temperature of 25° C. for 240 hours for equilibration; and has a contact angle with water of 70° or less, the contact angle measured using a contact angle measurement apparatus at a temperature of 25° C. by forming a droplet of pure water on a single layer of the hydrophilic polymer microparticles arranged with no space therebetween.

主权项

1. A hydrophilic polymer microparticle, comprising hydrophobic crosslinking monomers with a water solubility of 5% by weight or less and/or hydrophobic non-crosslinking monomers,
wherein the hydrophilic polymer microparticle has a DW/DA ratio of 2.0 or less,
wherein the DW represents a particle diameter of the hydrophilic polymer microparticle dispersed in water,wherein the DA represents a particle diameter of the hydrophilic polymer microparticle dispersed in acetone,wherein each of the particle diameters is measured by a particle size distribution analyzer after the hydrophilic polymer microparticle is dispersed in water or acetone, subjected to irradiation with ultrasonic waves for 15 minutes, and allowed to stand at a temperature of 25° C. for 240 hours for equilibration; wherein the hydrophilic polymer microparticle has a contact angle with water of 70° or less, the contact angle being measured using a contact angle measurement apparatus at a temperature of 25° C. by forming a droplet of pure water on a single layer of the hydrophilic polymer microparticles arranged with no space therebetween, and wherein the hydrophilic polymer microparticle has an uppermost surface processed with a hydrophilization treatment,
wherein the hydrophilization treatment is ozone water treatment, wherein the hydrophobic crosslinked polymer is obtained by
homopolymerizing one kind of hydrophobic crosslinking monomers;copolymerizing two or more kinds of hydrophobic crosslinking monomers; orcopolymerizing at least one kind of hydrophobic crosslinking monomers and at least one kind of hydrophobic non-crosslinking monomers,
wherein the amount of hydrophobic crosslinking monomer is 10 parts by weight or more to 100 parts by weight of all the monomers.