Morpholino nucleic acid derivatives

摘要

The present invention provides a useful morpholino nucleic acid derivative for synthesizing a morpholino nucleic acid oligomer. The present invention provides a compound represented by the following general formula (1) or a salt thereof.;
Here, R1 represents hydrogen, trityl and so on.

R2 represents an amide or an imine.

R3 represents a hydroxy group which may be protected by trialkylsilyl and so on, or a group represented by the following general formula (5):
;
(wherein X represents O or S, Y represents dialkylamino or alkoxy, and Z represents chlorine).

主权项

1. A compound represented by the following general formula (1) or a salt thereof:wherein
R1 represents hydrogen or a group represented by the following general formula (2)wherein * represents the binding position, and R11, R12, R13 are the same or different and each represents hydrogen, alkyl or alkoxy;
R2 represents a group represented by the following general formula (3) or (4)wherein *is defined as described above, R4 represents alkyl, arylmethyl or aryloxymethyl, and R5, R6 are the same or different and each represents alkyl; and
R3 represents a hydroxy group which may be protected by trialkylsilyl or diphenylalkylsilyl, or a group represented by the following general formula (5)wherein * is defined as described above, X represents O or S, Y represents dialkylamino or alkoxy, and Z represents halogen.