发明名称 |
Antioxidant small molecules aimed at targeting metal-based oxidative stress in neurodegenerative disorders |
摘要 |
Amine chelates capable of antioxidant capacity and amyloid disaggregation are shown which may be useful in targeting metal-based oxidative stress in neurodegenerative disorders. Pyclen, a backbone commonly investigated for contrast agent imaging, may be repurposed as an anti-oxidant chelator for disaggregating amyloid. The antioxidant capacity of pyclen was enhanced dramatically via conversion of the pyridine backbone to a pyridol with cellular studies showing superior antioxidant capacity while retaining chelation ability to protect amyloid from metal ions aggregation and also disaggregate amyloid aggregates. |
申请公布号 |
US8969548(B2) |
申请公布日期 |
2015.03.03 |
申请号 |
US201314105435 |
申请日期 |
2013.12.13 |
申请人 |
Texas Christian University |
发明人 |
Green Kayla Nalynn;Lincoln Kimberly Marie;Gonzalez Paulina |
分类号 |
C07D487/00;A61K31/4353 |
主分类号 |
C07D487/00 |
代理机构 |
|
代理人 |
Gunter, Jr. Charles D. |
主权项 |
1. A molecule having the structural formula: |
地址 |
Fort Worth TX US |