Methods of treating hepatic encephalopathy

摘要

The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin.

主权项

1. A method of decreasing a subject's risk of a hepatic encephalopathy (HE) breakthrough episode comprising administering rifaximin daily for a period of about 12 months or longer to a subject suffering from HE, thereby decreasing the subject's risk of an HE breakthrough episode, wherein a breakthrough episode is defined as an increase of the Conn score to Grade ≧2 or an increase in Conn score of 1 and asterixis grade of 1 for subjects having a baseline Conn score of 0.