Abuse-resistant controlled-release opioid dosage form

摘要

Abuse-resistant, controlled release opioid tablets are a combination containing an opioid antagonist such as naloxone at a level above that needed to suppress the euphoric effect of the opioid, if the combination were crushed to break the controlled release properties causing the opioid and opioid antagonist to be released as a immediate release product as a single dose. The controlled release nature of the table prevents the accumulation of orally effective amounts of opioid antagonist when taken normally. The opioid antagonist is contained in a controlled-release matrix and released, over time, with the opioid.

主权项

1. An oral controlled release pharmaceutical composition comprising a controlled release matrix containing:
10-160 mg oxycodone; and 5-160 mg naloxone; wherein the oxycodone and the naloxone are present in a ratio of 5:1 to 1:1; and wherein the controlled release matrix releases the naloxone and the oxycodone such that >90% of the naloxone is released from the composition over 10 hours.