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1. A compound of formula (I) [wherein Y is a hydrogen atom, lower alkyl optionally having substituent(s), lower alkoxy optionally having substituent(s), cycloalkyl optionally having substituent(s) or halogen, RA is a hydrogen atom, halogen, hydroxy, lower alkoxy, or lower alkyl, X is any one of the formula (b1)-(b16) (wherein RB-2 is lower alkyl optionally having substituent(s) or cycloalkyl optionally having substituent(s), RB is a hydrogen atom, lower alkyl optionally having substituent(s) or cycloalkyl optionally having substituent(s), and the broken line shows absent or a single bond), A is any one of the formula (a1)-(a29) (wherein R1, R2 and R3 are the same or different and each is a hydrogen atom, cyano, lower alkyl optionally having substituent(s), cycloalkyl optionally having substituent(s), halogen, lower alkoxy optionally having substituent(s), —NRFRG (wherein RF and RG are the same or different and each is a hydrogen atom, lower alkyl optionally having substituent(s), lower alkanoyl optionally having substituent(s), lower alkoxycarbonyl optionally having substituent(s) or aralkyl optionally having substituent(s), or RF and RG form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic group optionally having substituent(s)), lower alkylsulfanyl optionally having substituent(s), lower alkenyl optionally having substituent(s), lower alkanoyl optionally having substituent(s), lower alkoxycarbonyl optionally having substituent(s), carbamoyl, lower alkylcarbamoyl optionally having substituent(s), di-lower alkylcarbamoyl optionally having substituent(s), aliphatic heterocyclylcarbonyl optionally having substituent(s), aryloxy optionally having substituent(s), aryl optionally having substituent(s), aromatic heterocyclic group optionally having substituent(s), aliphatic heterocyclic group optionally having substituent(s), aralkyl optionally having substituent(s) or aralkyloxy optionally having substituent(s), RC, RD and RE are the same or different and each is a hydrogen atom, halogen, nitro, cyano, formyl, oxo, hydroxy, lower alkoxy optionally having substituent(s), —NRFaRGa (wherein RFa and RGa are as defined for the aforementioned RF and RG, respectively), lower alkanoyloxy optionally having substituent(s), lower alkyl optionally having substituent(s), lower alkenyl optionally having substituent(s), lower alkynyl optionally having substituent(s), lower alkanoyl optionally having substituent(s), lower alkoxycarbonyl optionally having substituent(s), lower alkylsulfonyl optionally having substituent(s), lower alkylsulfanyl optionally having substituent(s), cycloalkyl optionally having substituent(s) or —CONRHRI (wherein RH and RI are the same or different and each is a hydrogen atom, lower alkyl optionally having substituent(s), lower alkanoyl optionally having substituent(s), lower alkoxycarbonyl optionally having substituent(s) or aralkyl optionally having substituent(s), or RH and RI form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic group optionally having substituent(s)), RJ is a hydrogen atom, lower alkyl optionally having substituent(s), lower alkanoyl optionally having substituent(s), lower alkoxycarbonyl optionally having substituent(s), aryl optionally having substituent(s), lower alkylsulfonyl optionally having substituent(s), aralkyl optionally having substituent(s) or cycloalkyl optionally having substituent(s), and RK is a hydrogen atom, halogen, hydroxy, lower alkoxy, lower alkyl or —NRFbRGb (wherein RFb and RGb are as defined for the aforementioned RF and RG, respectively) wherein the substituents of the lower alkyl optionally having substituent(s), the lower alkylsulfonyl optionally having substituent(s), the lower alkenyl optionally having substituent(s), the lower alkynyl optionally having substituent(s), the lower alkoxy optionally having substituent(s), the lower alkylsulfanyl optionally having substituent(s), the lower alkanoyloxy optionally having substituent(s), the lower alkanoyl optionally having substituent(s), the lower alkoxycarbonyl optionally having substituent(s), the lower alkylcarbamoyl optionally having substituent(s), and the di-lower alkylcarbamoyl optionally having substituent(s) are the same or different and are 1 to 3 substituents selected from the group consisting of halogen, hydroxy, sulfanyl, nitro, cyano, carboxy, carbamoyl, C3-8 cycloalkyl, an aliphatic heterocyclic group, an aromatic heterocyclic group, C1-10 alkoxy, C3-8 cycloalkoxy, C6-14 aryloxy, C7-16 aralkyloxy, C2-11 alkanoyloxy, C7-15 aroyloxy, C1-10 alkylsulfanyl, —NRXRY (wherein RX and RY are the same or different and each represents a hydrogen atom, C1-10 alkyl, C3-8 cycloalkyl, C6-14 aryl, an atomatic heterocyclic group, C7-16 aralkyl, C2-11 alkanoyl, C7-15 aroyl, C1-10 alkoxycarbonyl or C7-16 aralkyloxycarbonyl), C2-11 alkanoyl, C7-15 aroyl, C1-10 alkoxycarbonyl, C6-14 aryloxycarbonyl, C1-10 alkylcarbamoyl and di-C1-10 alkylcarbamoyl, wherein the substituents of the aryl optionally having substituent(s), the aryloxy optionally having substituent(s), the aralkyl optionally having substituent(s), the aralkyloxy optionally having substituent(s) and the aromatic heterocyclic group optionally having substituent(s) are the same or different and are 1 to 3 substituents selected from the group consisting of halogen, hydroxy, sulfanyl, nitro, cyano, carbamoyl, C1-10 alkyl, trifluoromethyl, C3-8 cycloalkyl, C6-14 aryl, aliphatic heterocyclic group, aromatic heterocyclic group, C1-10 alkoxy, C3-8 cycloalkoxy, C6-14 aryloxy, C7-16 aralkyloxy, C2-11 alkanoyloxy, C7-15 aroyloxy, C1-10 alkylsulfanyl, —NRX1RY1 (wherein RX1 and RY1 are the same or different and each as defined above), C2-11 alkanoyl, C7-15 aroyl, C1-10 alkoxycarbonyl, C6-14 aryloxycarbonyl, C1-10 alkylcarbamoyl, and di-C1-10 alkylcarbamoyl, wherein the substituents of the cycloalkyl optionally having substituent(s), the aliphatic heterocyclic group optionally having substituent(s), the aliphatic heterocyclylcarbonyl optionally having substituent(s) and the nitrogen-containing heterocyclic group optionally having substituent(s) are the same or different and are 1 to 3 substituents selected from the group consisting of oxo, halogen, hydroxy, sulfanyl, nitro, cyano, carbamoyl, C1-10 alkyl, trifluoromethyl, C3-8 cycloalkyl, C6-14 aryl, aliphatic heterocyclic group, aromatic heterocyclic group, C1-10 alkoxy, C3-8 cycloalkoxy, C6-14 aryloxy, C7-16 aralkyloxy, C2-11 alkanoyloxy, C7-15 aroyloxy, C1-10 alkylsulfanyl, —NRX2RY2 (wherein RX2 and RY2 are the same or different and each is as defined above), C2-11 alkanoyl, C7-15 aroyl, C1-10 alkoxycarbonyl, C6-14 aryloxycarbonyl, C1-10 alkylcarbamoyl, and di-C1-10 alkylcarbamoyl, wherein the nitrogen-containing heterocyclic group is a 5-membered or 6-membered monocyclic heterocyclic group with 3- to 8-membered rings fused together, containing at least one nitrogen atom (said monocyclic heterocyclic group may contain other nitrogen atom(s), oxygen atom(s) or sulfur atom(s)); or a bicyclic or tricyclic fused heterocyclic group containing at least one nitrogen atom (said fused heterocyclic group may contain other nitrogen atom(s), oxygen atom(s) or sulfur atom(s)), wherein the aliphatic heterocyclic group and the aliphatic heterocyclic group moiety of aliphatic heterocyclylcarbonyl are respectively, a 5-membered or 6-membered monocyclic aliphatic heterocyclic group comprising at least one atom selected from a nitrogen atom, an oxygen atom and a sulfur atom; or a bicyclic or tricyclic condensed aliphatic heterocyclic group with 3- to 8-membered rings fused together containing at least one atom selected from a nitrogen atom, an oxygen atom and a sulfur atom, and wherein the aromatic heterocyclic group is a 5-membered or 6-membered monocyclic aromatic heterocyclic group containing at least one atom selected from a nitrogen atom, an oxygen atom and a sulfur atom; or a bicyclic or tricyclic condensed aromatic heterocyclic group with 3- to 8-membered rings fused together, containing at least one atom selected from a nitrogen atom, an oxygen atom and a sulfur atom], or a pharmaceutically acceptable salt thereof. |
