主权项 |
1. A compound of formula (I) or a salt thereof,whereinA is selected fromB is selected fromR1 is selected from chloro, fluoro and methyl;R2 is selected from chloro, fluoro, trifluoromethyl, methyl and cyano;R3 is selected from isopropyl, cyclopropyl, isobutyl, tert-butyl, cyclobutyl, cyclopentyl, or R3 is:wherein R14 is selected from OH, methoxy, NH2, NMe2, NHMe, NHCOMe and NHCOH;R4 is selected from
H, —(C0-C4)alkyl-phenyl, said phenyl being optionally substituted with 1, 2 or 3 substituents independently selected from:
(C1-C4)alkyl, optionally substituted by NR9(R10) or —O—(C1-C4)alkyl or by 1, 2 or 3 halo substituents,—O—(C1-C4)alkyl, optionally substituted by NR9(R10), phenyl or —O—(C1-C4)alkyl, or by 1, 2 or 3 halo substituents,—C(O)NR9(R12),cyano,halo,—(CH2)m—S(O)vNR9(R10),—C(O)OH,—C(O)O—(C1-C4)alkyl,—(CH2)p—NR9(R12),heterocyclyl1, andphenyl and wherein —(C0-C4)alkyl of said —(C0-C4)alkyl-phenyl, when present, is optionally substituted by 1 or 2 OH, —(C0-C4)alkyl-C(O)-phenyl, said phenyl being optionally substituted with 1, 2 or 3 substituents independently selected from:
(C1-C4)alkyl, optionally substituted with from 1 to 3 halo,—O—(C1-C4)alkyl,cyano, andhalo, naphthyl, —(C0-C4)alkyl-(C3-C6)cycloalkyl, said (C3-C6)cycloalkyl being optionally substituted with 1, 2 or 3 substituents independently selected from OH, —C(O)NR9(R10), —O—C(O)—(C1-C4)alkyl, halo, —(CH2)m—NR9(R10) and —C(O)—O(C1-C4)alkyl, —(C0-C4)alkyl-heteroaryl1, the heteroaryl1 of said —(C0-C4)alkyl-heteroaryl1 being optionally substituted by 1, 2, 3 or 4 substituents independently selected from —O—(C1-C4)alkyl, ═O, OH, cyano, (C1-C4)alkyl, halo and —NR9(R10), —(C0-C4)alkyl-C(O)NR9(R13), —(C0-C4)alkyl-NR9(R12), wherein —(C0-C4)alkyl of said —(C0-C4)alkyl-NR9(R12), when present, is optionally substituted with 1 or 2 OH, —(C0-C4)alkyl-heterocyclyl4, said heterocyclyl4 being optionally substituted by 1, 2, 3 or 4 substituents independently selected from
—O—C(O)NR9(R12),OH,—C(O)(C1-C4)alkyl, optionally substituted by (C1-C4)alkoxy,—C(O)—O(C1-C4)alkyl, optionally substituted by (C1-C4)alkoxy,═O,halo,—C(O)— heteroaryl2, and(C1-C4)alkyl, optionally substituted by phenyl,and wherein the —(C0-C4)alkyl of —(C0-C4)alkyl-heterocyclyl4, when present, is optionally substituted with 1 or 2 OH,
(C1-C8)alkyl, said (C1-C8)alkyl being optionally substituted by 1, 2 or 3 substituents independently selected from OH, halo, —O—(C1-C4)alkyl, —C(O)(C1-C4)alkyl, —C(O)O—-(C1-C4)alkyl, —C(O)OH, cyano and NR9(R10), (C1-C8)alkenyl, said (C1-C8)alkenyl being optionally substituted by 1, 2 or 3 substituents independently selected from OH, halo and —O—(C1-C4)alkyl;R5 is selected from:
H, heterocyclyl1-C(O)—(CH2)n—, (C1-C4)alkyl-, said (C1-C4)alkyl- being optionally substituted with 1 or 2 substituents independently selected from OH, ═O, heterocyclyl1-(C1-C4)alkyl-, wherein said alkyl of heterocyclyl1-(C1-C4)alkyl- is optionally substituted by 1 or 2 OH, and said heterocyclyl1 can be optionally substituted by methyl or ethyl, (C1-C4)alkyl-O—C(O)—(CH2)m— and cyano;R6 is selected from
H, (C1-C4)alkyl-, optionally substituted with (C1-C4)alkoxy, (C1-C4)alkoxy, optionally substituted with (C1-C4)alkoxy, (C1-C4)alkoxy(C1-C4)alkoxy(C1-C4)alkyl-, halo, R9(R10)N—C(O)—(CH2)m—, cyano R9(R10)N—(CH2)m—, R9(R10)N—(CH2)n—O—(CH2)m—, (C1-C4)alkyl-C(O)—(R10)N—(CH2)m—, and —O—(CH2)p-heteroaryl2;R7 is selected from
H, halo, (C1-C4)alkyl-, optionally substituted with (C1-C4)alkoxy, (C1-C4)alkoxy, optionally substituted with (C1-C4)alkoxy, (C1-C4)alkoxy(C1-C4)alkoxy(C1-C4)alkyl-, R9(R10)N—(CH2)n—O—(CH2)m—, and (C1-C4)alkyl-C(O)O—(CH2)n—(R10)N—;R8 is selected from
H, (C1-C4)alkoxy(C1-C4)alkyl-, (C1-C4)alkyl-, said (C1-C4)alkyl- being optionally substituted by 1, 2 or 3 substituents independently selected from OH, halo, —O—(C1-C4)alkyl, NR9(R10), and (C1-C4)alkyl-C(O)NR9(R10);R9 is H, methyl or ethyl;R10 is H, methyl or ethyl, wherein said methyl and ethyl can each independently be substituted by 1 or 2 substituents independently selected from methoxy, ethoxy and halo;R11 is H, methyl, methoxy or halo;R12 is selected from
H, (C1-C4)alkyl-, optionally substituted with heterocyclyl3, —C(O)(C1-C4)alkyl, —C(O)O(C1-C4)alkyl, —C(O)H, and —C(O)-phenyl, optionally substituted with 1 or 2 substituents independently selected from (C1-C4)alkyl, —O—(C1-C4)alkyl, cyano, halo, —C(O)OH, —C(O)O—(C1-C4)alkyl and —C(O)—(C1-C4)alkyl;R13 is selected from
—(C0-C3)alkyl-phenyl, said phenyl being optionally substituted with 1 or 2 substituents independently selected from (C1-C4)alkyl, —O—(C1-C4)alkyl, cyano, halo, —C(O)OH, —C(O)O—(C1-C4)alkyl and —C(O)—(C1-C4)alkyl, —(C0-C3)alkyl-heterocyclyl4, said heterocyclyl4 being optionally substituted by 1, 2 or 3 substituents independently selected from —O—(C1-C4)alkyl, C(O)(C1-C4)alkyl and C(O)O—(C1-C4)alkyl, (C1-C4)alkyl, said (C1-C4)alkyl being optionally substituted with a substituent independently selected from —O—(C1-C4)alkyl, C(O)(C1-C4)alkyl and C(O)O—(C1-C4)alkyl, —(C0-C3)alkyl-(C3-C6)cycloalkyl; or R9 and R13, together with the nitrogen to which they are attached form heterocyclyl3, said heterocyclyl3 being optionally substituted with 1, 2 or 3 substitutents selected independently from ═O, (C1-C4)alkyl, said (C1-C4)alkyl being optionally substituted with 1, 2 or 3 substitutents selected independently from halo and OH, OH, C(O)(C1-C4)alkyl, C(O)O—(C1-C4)alkyl and C(O)NR9R10;m is 0, 1 or 2;n is 1, 2 or 3;p is 0, 1, 2 or 3;v is 0, 1 or 2;heterocyclyl1 is a 3, 4, 5 or 6 membered fully saturated or partially unsaturated monocyclic group comprising ring carbon atoms and 1 or 2 ring heteroatoms independently selected from N, O and S;heterocyclyl3 is a 4, 5 or 6 membered fully saturated or partially unsaturated monocyclic group comprising ring carbon atoms and 1 or 2 ring heteroatoms independently selected from N, O and S;heterocyclyl4 is a 3, 4, 5, 6 or 7 membered fully saturated or partially unsaturated monocyclic group comprising carbon ring atoms and 1 or 2 ring atoms selected independently from N, O and S;heteroaryl1 is a 5, 6, 7, 8, 9 or 10 membered, mono or bicyclic, fully unsaturated or partially unsaturated group, comprising carbon ring atoms and 1, 2, 3 or 4 ring heteratoms independently selected from N, O and S, wherein the total number of S atoms does not exceed 1, and the total number of O atoms does not exceed 1;heteroaryl2 is 5 or 6 membered fully unsaturated monocyclic group comprising ring carbon atoms and 1, 2, 3 or 4 ring heteroatoms independently selected from N, O and S, wherein the total number of ring S atoms does not exceed 1, and the total number of ring O atoms does not exceed 1;and * indicates the point of attachment to the remainder of the molecule. |