发明名称 |
Matrix scaffold with antimicrobial activity |
摘要 |
The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides. |
申请公布号 |
US8969290(B2) |
申请公布日期 |
2015.03.03 |
申请号 |
US201313928245 |
申请日期 |
2013.06.26 |
申请人 |
Worcester Polytechnic Institute |
发明人 |
Rolle Marsha;Prifti Fioleda;Malcuit Chris;Camesano Terri Anne;Dominko Tanja;Kole Denis |
分类号 |
A61L27/54;C07K14/78;C07K14/47;C12N15/62 |
主分类号 |
A61L27/54 |
代理机构 |
Burns & Levinson, LLP |
代理人 |
Burns & Levinson, LLP ;Susan Janine M. |
主权项 |
1. A chimeric peptide comprising
MKTQRDGHSLGRWSLVLLLLGLVMPLAIIAQVLSYKEAVLRAIDGINQRSSDANLYRLL DLDPRPTMDGDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQA RGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES (SEQ ID NO: 4) and a collagen binding domain selected from the group consisting of TKKTLRT (SEQ ID NO: 5) and CQDSETGTFY (SEQ ID NO: 6), attached to the C-terminal end of SEQ ID NO: 4 via a linker sequence comprising five aspartic acid residues, two lysine residues and a tyrosine residue. |
地址 |
Worcester MA US |