| 发明名称 | Neuronal specific targeting of caveolin expression to restore synaptic signaling and improve cognitive function in the neurodegenerative brain and motor function in spinal cord | ||
| 摘要 | The invention provides an expression system for producing Caveolin-1 in neuronal cells or neural stem cells comprising a neuron-specific regulatory element and a nucleic acid sequence encoding Caveolin-1. | ||
| 申请公布号 | US8969077(B2) | 申请公布日期 | 2015.03.03 |
| 申请号 | US201113883503 | 申请日期 | 2011.11.07 |
| 申请人 | The Regents of the University of California | 发明人 | Head Brian P.;Patel Piyush M.;Patel Hemal;Roth David M. |
| 分类号 | A61K48/00;A61K31/7088;A61K38/17;C12N15/86 | 主分类号 | A61K48/00 |
| 代理机构 | Adriano & Associates | 代理人 | Adriano & Associates |
| 主权项 | 1. An expression system for producing Caveolin-1 specifically in neuronal cells or neural stem cells for growth and arborization comprising: (a) a neuron-specific regulatory element; and (b) a nucleic acid sequence encoding Caveolin-1 wherein the neuron-specific regulatory element of (a) is a promoter and located upstream of the nucleic acid sequence encoding Caveolin-1 of (b) and directs the expression of Caveolin-1 in neuronal cells or neural stem cells for growth and arborization. | ||
| 地址 | Oakland CA US | ||