Bioactive implant for myocardial regeneration and ventricular chamber restoration

摘要

Bioactive implant for myocardial regeneration and ventricular chamber support including an elastomeric microporous membrane. The elastomeric microporous membrane being at least one non-degradable polymer and at least one partially degradable polymer. The non-degradable polymer is selected from polyethylacrylate and polyethylacrylate copolymerized with a hydroxyethylacrylate comonomer. The partially degradable polymer is selected from caprolactone 2-(methacryloyloxy)ethyl ester and caprolactone 2-(methacryloyloxy)ethyl ester copolymerized with ethylacrylate. The elastomeric microporous membrane further includes a nanofiber hydrogel, and cells. The bioactive implant, having one or two helical loops, contributes to the restauration of the heart conical shape. Cardiac wrapping by ventricular support bioprostheses of the present invention, having reinforcement bands spatially distributed as helicoids, recovers the sequential contraction of the myocardium resulting in the successive shortening and lengthening of the ventricles, therefore improving the ejection (systolic function) and suction of blood (diastolic function).

主权项

1. A bioactive implant constituting a scaffold for myocardial regeneration and ventricular chamber support, comprising:
I. an elastomeric microporous membrane made from a mix of at least one non-degradable polymer and at least one partially degradable polymer, said membrane having a porosity comprised between 70% and 90%, the pores being interconnected and having diameters comprised between 50 microns and 500 microns, wherein (a) Said non-degradable polymer is selected from the group consisting of polyethylacrylate and polyethylacrylate copolymerized with a 10% wt or a 20% wt hydroxyethylacrylate comonomer; and (b) Said partially degradable polymer is selected from the group consisting of caprolactone 2-(methacryloyloxy)ethyl ester and caprolactone 2-(methacryloyloxy)ethyl ester copolymerized with ethylacrylate' in weight proportions of this last comonomer comprised between 30% and 80%, wherein a percentage of non-degradable polymers versus degradable polymers is comprised between 10% wt and 90% wt, II. a nanofiber hydrogel and III cells.