Encapsulated agglomeration of microcapsules and method for the preparation thereof

摘要

Microcapsules comprising an agglomeration of primary microcapsules, each individual primary microcapsule having a primary shell and the agglomeration being encapsulated by an outer shell, may be prepared by providing an aqueous mixture of a loading substance and a shell material, adjusting pH, temperature, concentration and/or mixing speed to form primary shells of shell material around the loading substance and cooling the aqueous mixture until the primary shells agglomerate and an outer shell of shell material forms around the agglomeration. Such microcapsules are useful for storing a substance and for delivering the substance to a desired environment.

主权项

1. A process for preparing a microcapsule, the process comprising:
(a) providing an aqueous mixture comprising (i) a biologically active loading substance and (ii) a first and a second polymer component; (b) adjusting pH, temperature, concentration, mixing speed or a combination thereof of the aqueous mixture to produce a shell material by complex coacervation of only the first and second polymer components, the shell material forming a primary shell around the loading substance, thereby producing a primary microcapsule; (c) cooling the aqueous mixture until a plurality of the primary microcapsules form an agglomeration; (d) further cooling the aqueous mixture to produce an outer shell of the shell material by complex coacervation of the first and second polymer components around the agglomeration; and (e) spray drying the aqueous mixture, to produce the microcapsule, wherein the first polymer component is gelatin and the second polymer component is polyphosphate and the microcapsule has not been crosslinked.