| 主权项 |
1. A compound of Formula I or Formula IIor a pharmaceutically acceptable salt of a compound of Formula I or Formula II, wherein:
X and Y are C(R11), wherein each R11 is independently selected from the group consisting of: hydrogen, halo and C1-4alkyl; B is selected from the group consisting of: —C(R5)(R6)-, and —C(R5)(R6)-C(R7)(R8)-; C is selected from the group consisting of aryl and heteroaryl, or a fused analog of aryl or heteroaryl, wherein the aryl and heteroaryl or fused analogs thereof are selected from the group consisting of phenyl, naphthyl, indanyl, indenyl, tetrahydronaphthyl, 2,3-dihydrobenzofuranyl, dihydrobenzopyranyl, 1,4-benzodioxyl, pyrrolyl, isozazolyl, isothiazolyl, pyrazolyl, pyridyl, oxazolyl, oxadiazolyl, thiadiazolyl, thiazolyl, imidazolyl, triazolyl, tetrazolyl, furanyl, triazinyl, thienyl, pyrimidyl, pyridazinyl, pyrazinyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, furo(2,3-b)pyridyl, quinolyl, indolyl, and isoquinolyl, each optionally substituted with one to three substituents independently selected from R10; E is selected from the group consisting of: —C(O)OH, —C(O)OC1-4alkyl, tetrazolyl andwherein R is selected from the group consisting of: C1-4alkyl, aryl and heteroaryl, or a fused analog of aryl or heteroaryl, wherein the aryl and heteroaryl or fused analogs thereof are selected from the group consisting of phenyl, naphthyl, indanyl, indenyl, tetrahydronaphthyl, 2,3-dihydrobenzofuranyl, dihydrobenzopyranyl, 1,4-benzodioxyl, pyrrolyl, isozazolyl, isothiazolyl, pyrazolyl, pyridyl, oxazolyl, oxadiazolyl, thiadiazolyl, thiazolyl, imidazolyl, triazolyl, tetrazolyl, furanyl, triazinyl, thienyl, pyrimidyl, pyridazinyl, pyrazinyl, benzoxazolyl, benzothiazolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, furo(2,3-b)pyridyl, quinolyl, indolyl, and isoquinolyl,wherein aryl and heterorayl or the fused analogs thereof are optionally substituted with one to three substituents independently selected from R10;
R1 to R8 are independently selected from the group consisting of: H, halo, —O—R12, C1-6alkyl and C3-6cycloalkyl, and one or more pairs of R1 and R2, R5 and R6, and R7 and R8 may be joined together with the carbon atom to which they are attached to form a 3- to 5-membered monocyclic cycloalkyl ring, and R5 and R6 or R7 and R8 may be joined together to form carbonyl; R9 is selected from the group consisting of: halo, hydroxy and C1-4alkyl; R10 is selected from the group consisting of: halo, cyano, C1-4alkyl, C1-4-fluoroalkyl, C1-4-alkoxy, C1-4-thioalkoxy and C1-4-fluoroalkoxy; and each R12 is selected from the group consisting of: H, C1-4alkyl, C3-6cycloalkyl and heterocyclyl. |
