Method for automated unloading of a microbial detection apparatus

摘要

The present invention is directed to a method and automated unloading means for unloading a container from an apparatus. The apparatus of the present invention may include a means for automated loading, a means for automated transfer and/or a means for automated unloading of a container (e.g., a specimen container). In one embodiment, the apparatus can be an automated detection apparatus for rapid non-invasive detection of a microbial agent in a test sample. The detection system also including a heated enclosure, a holding means or rack, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.

主权项

1. A method for automated unloading of “positive” and “negative” specimen containers from an automated detection apparatus for rapid non-invasive detection of microorganism growth in a test sample, said method comprising the following steps:
(a) providing one or more specimen containers having an internal chamber with a culture medium disposed therein for culturing any microorganisms that may be present in said test sample; (b) providing an automated detection apparatus, said apparatus comprising:
(i) a housing enclosing an interior chamber therein, said housing further comprising a “positive” container exit location for removing a specimen container determined as positive for microorganism growth from said housing interior chamber and a “negative” container exit location for removing a specimen container determined as negative for microorganism growth, wherein said positive container exit location is a positive container exit port and wherein said negative container exit location is a waste bin;(ii) a holding structure located within said housing, said holding structure comprising a plurality of wells each capable of holding one of said specimen containers;(iii) a detection unit located within said interior chamber to detect the presence of one or more by-products of microorganism growth; and(iv) a multi-axis robotic transfer arm, wherein said multi-axis robotic transfer arm comprises: at least one horizontal support rail in a first horizontal axis and a moveable vertical support rail, wherein said vertical support rail is supported by said at least one horizontal support rail and is capable of moving along said at least one horizontal support rail, a horizontal slide rail in a second horizontal axis, said horizontal slide rail supporting a movable robotic head and gripper mechanism, wherein said robotic head and gripper mechanism is capable of moving along said horizontal slide rail in said second horizontal axis, wherein said horizontal slide rail comprises a pivot plate and a pivot slot, wherein said robotic head and gripper mechanism are coupled to said pivot plate, wherein said pivot plate comprises a moveable pivot slot cam follower, wherein said pivot slot cam follower is moveable between a first position in said pivot slot and a second position in said pivot slot, and wherein said robotic head and gripping mechanism are rotated from a vertical orientation to a horizontal orientation by said movement from said first position in said pivot slot to said second position in said pivot slot; and (c) periodically monitoring said specimen containers for the presence and/or absence of one or more by-products of microorganism growth, and wherein said specimen containers are determined to be “positive” for microorganism growth therein by detection of said one or more by-products of microorganism growth or wherein said specimen containers are determined to be “negative” for microorganism growth when said one or more by-products of microorganism growth are not detected after a specified time period; and (d) automatically unloading said “positive” specimen containers from said apparatus by transferring said “positive” specimen containers from said holding structure to said positive container exit port using said multi-axis robotic transfer arm and automatically unloading said “negative” specimen containers from said apparatus by transferring said specimen containers from said holding structure to said waste bin using said multi-axis robotic transfer arm.