| 摘要 |
<p>#CMT# #/CMT# Preparation of acylglycinate compound (I) comprises reacting glycine with fatty acid chloride compound (II) in water and in the presence of an alkali base compound, which provides the cation, but in the absence of an organic solvent at 30-35[deg] C, where the portion of the fatty acid chloride contains less than 2 wt.% of acyl group with 18 or more carbon atoms, related to the total amount of the used fatty acid. #CMT# : #/CMT# Preparation of acylglycinate compound of formula ((R 1>-NH-CH 2-C(=O)-O ->) Q +>) (I) comprises reacting glycine with fatty acid chloride compound of formula (R 1>Cl) (II) in water and in the presence of an alkali base compound, which provides the cation, but in the absence of an organic solvent at 30-35[deg] C, where the portion of the fatty acid chloride contains less than 2 wt.% of acyl group with 18 or more carbon atoms, related to the total amount of the used fatty acid.R 1>= saturated 6-30C (preferably 8-18C) alkanoyl group or one or more unsaturated 6-30C (preferably 12-18C) alkenoyl group; and Q +>= a cation of alkali metal including Li +>, Na +>(preferred) or K +>. An independent claim is included for a composition comprising: (a) 21-28 wt.% of one or more (I), where a portion of (I) comprises less than 2 (preferably 1.8) wt.% of acyl groups; (b) >= 1 wt.% of one or more chlorinated substances of formula (Q +>Cl ->) (III); (c) less than 2 wt.% (preferably greater than 0.1 wt.% and less than 2 wt.%) of one or more fatty acid salt of formula (R 2>-C(=O)-O ->Q +>) (IV); and (d) water, but devoid of organic solvent. R 2>R 1>. #CMT#USE : #/CMT# The composition comprising (I) is useful: for preparing a cosmetic preparation; and as a surfactant in the cosmetic preparation (all claimed). #CMT#ADVANTAGE : #/CMT# The method produces (I) with high purity without using the organic solvent. The method uses highly concentrated saline glycinate solution with a low content of by product such as fatty acid salt, thus the method is easy to handle and cost effective as it does not require any separation step to remove organic solvent such as lower alcohols, diols or other solvents. The composition can be used directly without further purification. #CMT#ORGANIC CHEMISTRY : #/CMT# Preferred Method: The method is carried out at a pH of 9-13 (preferably 12-13). Preferred Components: The used alkali compound is carbonate or hydroxide (preferred) and the alkali metal cation is sodium hydroxide (preferred) and/or potassium hydroxide. The molar ratio of glycine to fatty acid chloride is 1.1:1 to 1:1 (preferably 1.05:1 to 1:1). Preferred Composition: The composition comprises 23-27 wt.% of (a), preferably sodiumcocoylglycinate with 8-18C acyl group, where: the portion of (I) with 18C acyl group is less than 2 w.% (preferably 1 wt.%); the portion of (I) together with 8-10C acyl group is greater than 5 (preferably 10-14) wt.%; or the portion of (I) with 12C acyl group of 50-72 wt.%. The composition comprises: (I), where R 1>is 12C acyl group and additionally one or more (I) where R 1>is 14C acyl group; 1-8 (preferably 4-6) wt.% of (III); less than 1.8 (preferably less than 1) wt.% of (II). The composition has a viscosity at 35[deg] C of less than 5000 mPas, preferably 500-1000 mPas. #CMT#EXAMPLE : #/CMT# Glycine (37.8 g) was dissolved in deionized water (276 g) under stirring and the pH was adjusted to 12-13 with sodium hydroxide solution. Subsequently, the mixture was heated to 30-35[deg] C under stirring and cocoyl chloride (106.4 g) was added within 6 hours at 30-35[deg] C under cooling the reaction mixture. The pH was maintained at 12-13 during the addition of the 33% sodium hydroxide solution and at the end of the addition of cocoyl chloride the pH decreases to 9.5-10.5. The reaction mixture was stirred for 2 hours at the pH of 9.5-10.5 to obtain acylglycinate.</p> |
