| 发明名称 |
SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES |
| 摘要 |
The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N-R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof. |
| 申请公布号 |
HRP20141259(T1) |
申请公布日期 |
2015.02.27 |
| 申请号 |
HR2014P001259T |
申请日期 |
2014.12.24 |
| 申请人 |
NOVARTIS AG |
发明人 |
BERGHAUSEN, JOERG;BUSCHMANN, NICOLE;FURET, PASCAL;GESSIER, FRANÇOIS;HERGOVICH LISZTWAN, JOANNA;HOLZER, PHILIPP;JACOBY, EDGAR;KALLEN, JOERG;MASUYA, KEIICHI;PISSOT SOLDERMANN, CAROLE;REN, HAIXIA;STUTZ, STEFAN |
| 分类号 |
A61P35/00;A61K31/495;C07D217/24;C07D401/04;C07D401/10;C07D401/12;C07D401/14;C07D405/04;C07D405/12;C07D405/14;C07D409/12;C07D413/10;C07D413/12;C07D413/14;C07D417/12 |
主分类号 |
A61P35/00 |
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