Histone deacetylase inhibitors and compositions and methods of use thereof

摘要

The disclosure relates to substituted phenylcyclopropanecarboxamide derivatives of formula (I) and pharmaceutically acceptable salt thereof, which are histone deacetylase (HDAC) inhibitors, wherein the variables are as defined in the specification. These compounds of formula (I) are suitable for treating a condition or disorder mediated by at least one histone deacetylase in a subject, and therefore useful for treating a neurodegenerative pathology, particularly Huntington’s disease.