COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS

摘要

The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Pte loss-of-function, hedgehog gain­ of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.