发明名称 |
METHOD OF DIFFERENTIATING MAMMALIAN PROGENITOR CELLS INTO INSULIN PRODUCING PANCREATIC ISLET CELLS |
摘要 |
The invention relates to methods for differentiating progenitor cells into insulin producing pancreatic islet cells and compositions and methods for using such cells. |
申请公布号 |
US2015056647(A1) |
申请公布日期 |
2015.02.26 |
申请号 |
US201414530251 |
申请日期 |
2014.10.31 |
申请人 |
Vesta Therapeutics Inc. |
发明人 |
RUIZ Joseph Charles;HOYNOWSKI Steven Michael |
分类号 |
C12N5/071 |
主分类号 |
C12N5/071 |
代理机构 |
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代理人 |
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主权项 |
1. A method for differentiating progenitor cells into insulin-producing pancreatic cells, comprising:
(a) incubating the progenitor cells in serum-free pre-induction media comprising a histone deacetylase inhibitor (HDACI); and, subsequently, (b) incubating the progenitor cell in induction media comprising knock-out replacement serum; for a time sufficient to differentiate the progenitor cells into insulin producing pancreatic cells. |
地址 |
Durham NC US |