发明名称 |
METHOD FOR PRODUCING LIPOSOME ENCAPSULATING PACLITAXEL MONOGLYCOSIDE AND/OR DOCETAXEL MONOGLYCOSIDE |
摘要 |
In order to reduce the side effects of paclitaxel derivatives having excellent anti-cancer effects, an attempt was made to produce a liposome encapsulating paclitaxel derivatives such as paclitaxel monoglycosides and docetaxel monoglycosides. However, the introduction efficiency of paclitaxel derivatives, etc., into a liposome was poor, and this technique was not developed to a practical level. The present invention provides a method for producing a liposome encapsulating a paclitaxel monoglycoside and/or a docetaxel monoglycoside, and having an antibody specifically recognizing a cancer cell, the method comprising a step of bringing a liposome encapsulating a polyoxyethylene ester derivative, a lower alcohol, and a buffer or water into contact with a solution in which a paclitaxel monoglycoside and/or a docetaxel monoglycoside is dissolved in an alkylene glycol-containing buffer or water. |
申请公布号 |
US2015056270(A1) |
申请公布日期 |
2015.02.26 |
申请号 |
US201314386855 |
申请日期 |
2013.03.22 |
申请人 |
HAMADA Hiroki;FUJIWARA Ichiro;ENSUIKO SUGAR REFINING CO., LTD. ;NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY |
发明人 |
Hamada Hiroki;Fujiwara Ichiro;Seno Masaharu;Kasai Tomonari;Shigehiro Tsukasa;Murakami Masaharu;Mikuni Katsuhiko |
分类号 |
A61K47/48;A61K31/337 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
1. A method for producing a liposome encapsulating a paclitaxel monoglycoside and/or a docetaxel monoglycoside, and having an antibody specifically recognizing a cancer cell,
the method comprising a step of bringing a liposome encapsulating a polyoxyethylene ester derivative, a lower alcohol, and a buffer or water into contact with a solution in which a paclitaxel monoglycoside and/or a docetaxel monoglycoside is dissolved in an alkylene glycol-containing buffer or water. |
地址 |
Okayama JP |