DIAGNOSTIC METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER

摘要

The invention provides methods and compositions to detect expression of one or more biomarkers for identifying and treating patients who are likely to be responsive to VEGF antagonist therapy. The invention also provides kits and articles of manufacture for use in the methods.

主权项

1. A method of determining whether a patient is likely to respond to treatment with a VEGF antagonist, the method comprising:
(a) detecting expression of at least one of the following genes, DLL4, angiopoietin 2 (Angpt2), NOS2, Factor V, Factor VIII (AHF), EGFL7, EFNA3, PGF, ANGPTL1, SELP, Cox2, Fibronectin (FN_EIIIB), ESM1, and stromal derived growth factor (SDF1), in a biological sample obtained from the patient prior to any administration of a VEGF antagonist to the patient; (b) comparing the expression level of the at least one gene to a reference expression level of the at least one gene, wherein a change in the level of expression of the at least one gene in the patient sample relative to the reference level identifies a patient who is likely to respond to treatment with a VEGF antagonist; and (c) informing the patient that they have an increased likelihood of being responsive to treatment with a VEGF antagonist.