| 摘要 |
Provided are functional segregated telodendrimers having, for example, two or three functional segments. The telodendrimers can have one or more crosslinking groups (e.g., reversible photocrosslinking groups). The telodendrimers can aggregate to form nanocarriers. Cargo such as drugs, imaging probes, and other materials may be sequestered in the core of the aggregates via non-covalent or covalent interactions with the telodendrimers. Such nanocarriers may be used in drug delivery applications and imaging applications. |
| 主权项 |
1. A compound of formula (I): wherein
PEG is optionally present and is a polyethylene glycol moiety, wherein PEG has a molecular weight of 44 Da to 100 kDa;A is a monomer or oligomer;X is a branched monomer unit;each L1 is independently optional and is a linker group;each L2 is independently optional and is a linker group;D1 is optional and is a dendritic polymer moiety having one or more branched monomer units (X), a plurality of end groups, and optionally, one or more linker groups L1;D2 is a dendritic polymer having one or more branched monomer units (X), a plurality of end groups, and optionally, one or more linker groups (L3);each L3 is independently optional or a linker group linked to the focal point group of the dendritic polymer and monomer unit (X);R1 and R2 are end groups of the dendritic polymer and are independently at each occurrence in the compound selected from the group consisting of a hydrophobic group, a hydrophilic group, an amphiphilic group, a reversible photocrosslinking group, and a drug, such that when R1 and/or R2 are not end groups each R1 and/or R2 is linked to one of the end groups;subscript x is an integer from 1 to 64, wherein subscript x is equal to the number of end groups on the dendritic polymer;subscript y is an integer from 2 to 64, wherein subscript y is equal to the number of end groups on the dendritic polymer;subscript p is an integer from 1 to 32; andsubscript m is an integer from 0 to 32. |
