CONTROL OF PROTEIN GLYCOSYLATION BY CULTURE MEDIUM SUPPLEMENTATION AND CELL CULTURE PROCESS PARAMETERS
摘要
<p>The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.</p>
申请公布号
WO2015026846(A1)
申请公布日期
2015.02.26
申请号
WO2014US51727
申请日期
2014.08.19
申请人
BIOGEN IDEC MA INC.
发明人
YANG, WILLIAM;HUANG, YAO-MING;MCELEARNEY, KYLE;TESCIONE, LIA;LAMBROPOULOS, JAMES;ZHANG, AN;TSANG, VALERIE;RYLL, THOMAS