AUTOMATIC SYSTEM FOR SYNTHESIZING 123I-MIBG AND AUTOMATIC DEVICE FOR SYNTHESIZING AND DISPENSING 123I-MIBG COMPRISING THE SAME

摘要

The present invention relates to an automatic system for synthesizing iodine-123 meta-iodobenzylguanidine (123I-MIBG), which comprises a first reactor for subjecting radioactive iodine-containing sodium iodide and meta-iodobenzylguanidine (MIBG) sulfate to an iodine-iodine exchange reaction to obtain radioactive iodine labeled MIBG; a purification unit for purifying the iodine labeled MIBG; and a second reactor for substituting a solvent used in purification with a phosphate buffer to obtain a phosphate solution containing 123I-MIBG. The present invention also relates to an automatic device for dispensing 123I-MIBG, which comprises the automatic system for synthesizing 123I-MIBG, a radioactivity measuring unit, and a dispensing and packing unit.

主权项

1. An automatic system for synthesizing iodine-123 meta-iodobenzylguanidine 123I-MIBG), comprising:
a first reactor, for subjecting radioactive iodine-containing sodium iodide and meta-iodobenzylguanidine (MIBG) sulfate, which are fed into the first reactor through a line and under the control of a solenoid valve, to an iodine-iodine exchange reaction to obtain radioactive labeled MIBG; a purification unit, for performing elution purification on the radioactive iodine labeled MIBG, which is fed into the first reactor through the line by using the solenoid valve, by means of column chromatography with water and ethanol, to collect a fraction eluted with the ethanol; and a second reactor, for distilling an ethanol eluent purified by the purification unit to remove the ethanol, and then placing a phosphate buffer is fed to obtain a phosphate buffered solution containing 123I-MIBG.