METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE

摘要

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Trefoil factor 3 as diagnostic and prognostic biomarker assays in renal injuries.

主权项

1. A method for evaluating renal status in a subject, comprising:
obtaining a urine sample from a subject selected for evaluation based on a determination that the subject is at risk of a future or current acute renal injury; performing an assay method configured to detect Trefoil factor 3 by introducing the urine sample obtained from the subject to into an assay instrument that (i) contacts all or a portion of the urine sample with a binding reagent which specifically binds for detection Trefoil factor 3, (ii) generates an assay result indicative of binding of Trefoil factor 3 to the binding reagent; and correlating the assay result to the renal status of the subject by using the assay result to assign the patient to a predetermined subpopulation of individuals having a known predisposition of a future acute renal injury.