Compositions And Methods For Immunodominant Antigens

摘要

Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens (Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis, human Herpes virus 1 and 2, Mycobacterium tuberculosis, Plasmodium falciparum, and Vaccinia virus) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter.

主权项

1. An isolated antigen composition comprising:
a plurality of immunodominant antigens of a pathogenic organism associated with a carrier; wherein the antigens have quantified and known relative reactivities with respect to sera of a population infected with the organism; wherein the antigens are determined to have a known association with a disease parameter; and wherein the plurality of antigens are encoded by nucleic acids selected from the group consisting of SEQ ID NO:633 (BB_A19), SEQ ID NO:575 (BB_A25), SEQ ID NO:595 (BB_K07), SEQ ID NO:596 (BB_K12), SEQ ID NO:14 (BB—0147), SEQ ID NO:550 (BB—0279), and SEQ ID NO: 637 (VIsE), or fragments thereof.