| 摘要 |
PROBLEM TO BE SOLVED: To provide an effective method in studies and treatments of hyperproliferative or neoplastic cells (e.g., cancer cells) and hyperproliferative or neoplastic conditions (e.g., cancer) in patients.SOLUTION: The invention provides a method for killing hyperproliferative cells comprising the step of contacting a hyperproliferative cell to an isolated oncolytic rhabdovirus. The rhabdovirus has a reduced nerve virulence, and may be related to, for example, non-vesicular stomatitis virus (VSV) rhabdovirus, but not limited to these. In certain aspects, rhabdovirus that encode or contain one or more protein components or a nucleic acid genome distinct from those of VSV and/or that have been constructed with one or more mutations or variations as compared to a wild-type virus or viral proteins such that the virus has desirable properties for use against cancer cells, while being less toxic or non-toxic to non-cancer cells than the virus as originally isolated or VSV. |
