发明名称 |
INHIBITORS OF INFLUENZA VIRUSES REPLICATION |
摘要 |
PROBLEM TO BE SOLVED: To provide inhibitors of influenza virus replication.SOLUTION: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient comprise administering to the biological sample or patient an effective amount of a compound represented by structural formula (I) or a pharmaceutically acceptable salt thereof, where the values of structural formula (IA) are as described herein. A compound is represented by structural formula (IA) or a pharmaceutically acceptable salt thereof, where the values of structural formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. |
申请公布号 |
JP2015038146(A) |
申请公布日期 |
2015.02.26 |
申请号 |
JP20140230556 |
申请日期 |
2014.11.13 |
申请人 |
VERTEX PHARMACEUTICALS INC |
发明人 |
CHARIFSON PAUL S;CLARK MICHAEL P;UPUL K BANDARAGE;BETHIEL RANDY S;COURT JOHN J;DENG HONGBO;IOANA DAVIES;DUFFY JOHN P;FARMER LUC J;GAO HUAI;GU WENXIN;DYLAN H JACOBS;JOSEPH M KENNEDY;LEDEBOER MARK W;LEDFORD BRIAN;MALTAIS FRANCOIS;EMANUELE PEROLA;WANG TIANSHENG;M WOODS WANNAMAKER;BYRN RANDAL;II CHOU;LIN CHAO;JIANG MIN;JONES STEVEN;URSULA A GERMANN;SALITURO FRANCESCO G;KWONG ANN DAK-YEE |
分类号 |
C07D471/04;A61K31/506;A61K31/5377;A61K31/541;A61K31/55;A61K31/551;A61K31/553;A61K31/675;A61P31/16;C07D519/00;C07F9/6561 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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