| 主权项 |
1. An implant for biomedical applications or a biomedical coating composition comprising a supramolecular material that comprises:
(a) a polymer comprising at least three 4H-units; and (b) a biologically active compound;
wherein the supramolecular material comprises 50.00-99.99 percent by weight of the polymer and 0.01-50.00 percent by weight of the biologically active compound, based on the total weight of the supramolecular material; andwherein the 4H-units have the general formula (3) or formula (4) and tautomers thereof: wherein X is nitrogen atom or a carbon atom bearing a substituent R8 and wherein R1, R2, R3 and R8 are independently selected from the group consisting of: (i) hydrogen; (ii) C1-C20 alkyl; (iii) C6-C12 aryl; (iv) C7-C12 alkaryl; (v) C7-C12 alkylaryl; (vi) polyester groups having the formula (5): wherein R4 and Y are independently selected from the group consisting of hydrogen and C1-C6 linear or branched alkyl, n is 1 to 6, and m is 10 to 100; (vii) C1-C10 alkyl groups substituted with 1-4 ureido groups according to the formula (6):
R5—NH—C(O)—NH— (6)wherein R5 is selected from the group consisting of hydrogen and C1-C6 linear or branched alkyl; and (vii) polyether groups having the formula (7): wherein R6, R7 and Y are independently selected from the group consisting of hydrogen and C1-C6 linear or branched alkyl and o is 10 to 100;wherein the at least three 4H-units are bonded to the backbone of the polymer via R1 and R2, while R3 represents a side chain according to (i)-(viii), or via R1 and R3, while R2 represents a side chain according to (i)-(viii); andwherein the polymer is derived from polymers having two terminal hydroxyl groups, the polymer being selected from the group consisting of polyethers, polyesters, polycarbonates, polyorthoesters, and copolymers from these polymers. |
