Benzimidazole derivs anthelmintic, antifung - al bactericidal, aericidal, insecticidal, nema

摘要

Benzimidazole derivs; anthelmintic, antifungal, bactericidal, acaricidal, insecticidal, nematocidal. Cpds. of formula (I): (where R is 1-4 substituents chosen from halo, alkyl, aryl, alkoxy, alkylthio, CN, NO2; R1 is H, alkyl, alkenyl, aryl, aralkyl, trihalomethylthio, ethylthio or vinylthio in which at least 2 of the H atoms are replaced by halogen, -CZ-Y-R4 (III) A1 is alkyl, alkenyl, aralkyl, aralkenyl, cycloalkyl, cycloalkyl-alkyl, aryl, heteroaryl, heteroaralkyl (these gps. are opt. substd. by halo, alkoxy, NO2, CN) dialkylamino or nitrogen heterocyclic joined by the N atom (the heterocyclic opt. contains an oxygen or a second nitrogen, and has an alkyl and/or cycloalkyl residue contg. 1-12 atoms of C; A2 is H or lower alkyl or A1 and A2 together are opt. unsatd. divalent hydrocarbyl, a heterocarbon gp. contg. an S, O or N atom. these groups opt. contain an alkyl and/or cycloalkyl gp. contg. 1-12C atoms; Y and Z are O or S; R4 is alkyl, alkenyl, aralkyl, aralkenyl, phenyl, naphthyl, cycloalkyl, cycloalkylalkyl, furyl, thienyl, pyridyl, thiazolyl, oxazolyl, isothiazolyl, isoxazolyl, thiadiazolyl (all opt. substd. by halo, alkyl, phenyl, alkoxy, alkylthio, cyano, nitro or dialkylamino); R2 is H, alkyl, aryl (e.g. phenyl, naphthyl), heteroaryl, these gps. opt. substd. by halo, alkyl, phenyl, alkoxy, alkylthio, cyano, nitro; R3 is alkyl, alkenyl, aralkyl, aralkenyl, cycloalkyl, cycloalkyl-alkyl, phenyl, naphthyl, furyl, thienyl, pyridyl, thiazolyl, oxazolyl, isothiazolyl, isoxazolyl or thiadiazolyl (all opt. substd. by one or more halo, alkyl, phenyl, alkoxy, alkylthio, CN, NO2, dialkylamino) or an N-contg. heterocyclic joined via the N-atom (the heterocyclic may contain an oxygen or a second nitrogen atom and has an alkyl and/or cycloalkyl residue contg. 1-12 C atoms); when R2 = H or unsatd. alkyl, R3 must be a heteroaryl as above or one of the other gps. which carries a substituent nitrogen except when R1 is a Group II in which A1 is a residue carrying an N-substituent or A1 and A2 together form a divalent heterocarbon gp.).