发明名称 |
RODENT PLASMODIUM PARASITES AS PLATFORMS FOR A WHOLE-ORGANISM MALARIA VACCINE |
摘要 |
A method for inducing protective immunity in a vertebrate host against malaria, by administering to the host a live rodent Plasmodium organism and exploiting its cross-species protection potential. A method to use genetically engineered live rodent Plasmodium organisms expressing antigens from different stages of the life cycle of human-infective Plasmodium species to immunize vertebrate hosts against malaria. The invention further provides for the production of a vaccine composition, by suspending wild-type or genetically modified rodent Plasmodium organisms in a suitable pharmaceutically acceptable carrier solution. |
申请公布号 |
EP2838554(A1) |
申请公布日期 |
2015.02.25 |
申请号 |
EP20130726295 |
申请日期 |
2013.04.17 |
申请人 |
INSTITUTO DE MEDICINA MOLECULAR |
发明人 |
PRUDÊNCIO PIGNATELLI, RUI MIGUEL;DIAS DA MOTA, MARIA MANUEL;BARBEIRO MENDES, ANTÓNIO MANUEL |
分类号 |
A61K39/015 |
主分类号 |
A61K39/015 |
代理机构 |
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