METHODS AND COMPOSITIONS FOR TREATING -THALASSEMIA AND SICKLE CELL DISEASE

摘要

The present invention provides compounds (such as compounds of formula I-a) that induce γ globin expression and pharmaceutical compositions thereof. Such compounds may have beneficial therapeutic effects. Compounds and compositions described herein may be used to treat hemoglobinopathies such as &bgr;-thalassemia and sickle cell anemia.