摘要 |
The present invention relates to a method for screening a substance for preventing or treating muscular atrophy using an animal cell strain into which nucleotide inhibiting expression of dystrophin polynucleotide is introduced, and the cell strain. According to the present invention, the cell strain maintains inhibition of expression of dystrophin mRNA and protein, delays time for thin muscle tube formation, and reduces expression of dystrophin composite protein. Therefore, the cell strain has cell physiology and biochemical characteristics similar with muscular atrophy and thus can be effectively used for a method for screening a substance for preventing or treating muscular atrophy. |