发明名称 |
Adenoviral-based biological delivery and expression system for use in the treatment of osteoarthritis |
摘要 |
<p>The invention relates to an adenoviral-based biological delivery and expression system for use in the treatment or prevention of osteoathritis in human or mammalian joints by long-term inducible gene expression of human or mammalian interleukin-1 receptor antagonist (II-1Ra) in synovial cells, comprising a helper-dependent adenoviral vector containing a nucleic acid sequence encoding for human or mammalian interleukin-1 receptor antagonist (II-1Ra), left and right inverted terminal repeats (L ITR and R ITR), the adenoviral packaging signal and non-viral, non-coding stuffer nucleic acid sequences, wherein the expression of the human or mammalian interleukin-1 receptor antagonist (II-1Ra) gene within synovial cells is regulated by an inflammation-inducible promoter.</p> |
申请公布号 |
EP2623604(B1) |
申请公布日期 |
2015.02.25 |
申请号 |
EP20120000703 |
申请日期 |
2012.02.02 |
申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
LEE, BRENDAN;GUSE, KILIAN;RUAN, ZHECHAO |
分类号 |
C12N15/86;A61K48/00 |
主分类号 |
C12N15/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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