Antibody Fc mutants with ablated effector functions

摘要

Antibody and other Fc-containing molecules with variations in the Fc region reduce binding to Fc gamma receptors and resulting activity and can be used in the treatment of various diseases and disorders.

主权项

1. An isolated Fc-containing molecule having decreased affinity for at least FcγRI and FcγRIIa as compared to an Fc-containing molecule with a wildtype Fc domain, comprising an antibody Fc domain with a mutated IgG2 constant region comprising the mutations V234A, G237A, P238S, H268A, V309L, A330S and P331S, wherein residue numbering is according to the EU numbering system.