Membrane-coated particles

摘要

A membrane-coated particle composition and methods comprising a particle surrounded by a native cell membrane are disclosed. The cell membrane may contain selected receptors or binding components. At least a portion of the receptors or binding components are oriented on the membrane-coated particle in the same or similar orientation as in the native cell membrane. The membrane-coated particle(s) finds use, for example, in contexts of basic research, proteomics, drug discovery, drug delivery, medical diagnostics, and aspects of patient care.

主权项

1. A composition comprising:
a particle having an exterior surface, a coating comprising membrane portions of lysed whole cells at least partially surrounding the particle; and at least one component associated with the membrane portions, the component having a binding affinity for a ligand upon contact with the component; wherein at least 5% of said at least one component is in the same external orientation in the coating as in the whole cells; and wherein the membrane portions are fluidly localized above the particle exterior surface.